Association of synuclein alpha (SNCA) gene polymorphisms with spontaneous brain activity in patients with Parkinson’s disease
Our study found a correlation of the <i>SNCA</i> SNPs rs11931074, rs356219, and rs356165 with brain functional alterations in patients with PD. Furthermore, an interaction effect was found in the right inferior parietal gyrus only for rs356219. This study may contribute to furthering the understanding of the influence of <i>SNCA</i> gene SNPs on brain function in patients with PD.
Authors
- Guoen Cai (ORCID: https://orcid.org/0000-0001-9566-0391)
- Xiaochun Chen (ORCID: https://orcid.org/0000-0002-9228-0198)
- Lina Chen (ORCID: https://orcid.org/0000-0002-2423-2418)
- Wenjing Song (ORCID: https://orcid.org/0000-0001-8696-043X)
- Yunjing Li (ORCID: https://orcid.org/0000-0001-5747-6155)
- Qinyong Ye (ORCID: https://orcid.org/0000-0002-1412-7518)
- Fengxian Chen (ORCID: https://orcid.org/0000-0002-6231-7930)
- Jing Jian
- Haoling Xu
- Ying-Qing Wang
Institutions
- Fujian Medical University (CN)
- Union Hospital (CN)
- The Second Affiliated Hospital of Xiamen Medical College
Publication Details
- Journal
- Quantitative Imaging in Medicine and Surgery
- Published
- 2024-09-01
- DOI
- https://doi.org/10.21037/qims-24-14
- Citations
- 2
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.74
Funders
- Fujian Medical University