Single‐cell <scp>RNA</scp> sequencing integrated with bulk <scp>RNA</scp> sequencing analysis reveals the protective effects of lactate‐mediated lactylation of microglia‐related proteins on spinal cord injury
In the subacute phase of SCI, metabolic remodeling in microglia may be key therapeutic targets to promote nerve regeneration, and lactate contributed to neuroprotection after SCI by influencing microglial lactylation and inflammatory phenotype, which offered a novel approach for therapeutic intervention.
Authors
- Chenglong Ji
- Yangyang Shi (ORCID: https://orcid.org/0000-0002-5024-384X)
- Kaiqiang Sun (ORCID: https://orcid.org/0000-0002-0272-8383)
- Bin Zhang (ORCID: https://orcid.org/0009-0007-9191-9977)
- Fudong Li (ORCID: https://orcid.org/0000-0002-3407-0715)
- Qing‐Jie Kong (ORCID: https://orcid.org/0000-0002-3788-305X)
- Xiaofei Sun
Institutions
- Second Military Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Changzheng Hospital (CN)
- Shanghai First People's Hospital (CN)
- PLA Navy General Hospital (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1111/cns.70028
- Citations
- 22
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.44
Funders
- National Natural Science Foundation of China