Sortilin is associated with progranulin deficiency and autism‐like behaviors in valproic acid‐induced autism rats
Collectively, our findings highlight elevated sortilin levels in ASD rat brains, exacerbating dendrite impairment by affecting PGRN expression. PGRN supplementation and SORT1 knockdown hold potential as therapeutic strategies for ASD.
Authors
- Yan Wang (ORCID: https://orcid.org/0000-0001-6555-9946)
- Ailing Liao (ORCID: https://orcid.org/0009-0006-8573-6958)
- Di Chen (ORCID: https://orcid.org/0000-0002-3720-5267)
- Wenxia Zheng
- Shali Wang
- Yingbo Li
- Nashi Wang
Institutions
- Chongqing Population and Family Planning Science and Technology Research Institute (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1111/cns.70015
- Citations
- 6
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 2.06
Funders
- Natural Science Foundation of Chongqing