Heterogeneous response of estimated insulin sensitivity indices to metformin in young individuals with type 1 diabetes and different phenotypes
The study showed that eGDR improved independently of basal weight after metformin treatment. However, the K<sub>ITT</sub> and SEARCH indices improved only in the obese group. Triglycerides and uric acid are associated with insulin sensitivity indices. These results highlight the heterogeneity of the mechanisms underlying insulin resistance and its response to metformin in individuals with T1D.
Authors
- Luana A. L. Ramaldes
- Sarah Simaan dos Santos (ORCID: https://orcid.org/0000-0001-6550-5825)
- Patrícia Médici Dualib (ORCID: https://orcid.org/0000-0003-0358-1034)
- Sérgio Atala Dib (ORCID: https://orcid.org/0000-0001-8653-8773)
- João Roberto de Sá (ORCID: https://orcid.org/0000-0003-3115-5606)
Institutions
- Faculdade de Medicina do ABC (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1186/s13098-024-01451-4
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00