HIV-1 Elite Controllers Are Characterized by Elevated Levels of CD69-Expressing Natural Killer Cells
These findings demonstrate that NK cells from ECs have an activated, mature profile with low levels of immune exhaustion and a reduced metabolic phenotype suggesting functional competence. This insight could inform the development of novel immunotherapeutic strategies for treating HIV-1.
Authors
- Neil Alexander Martinson (ORCID: https://orcid.org/0000-0002-0184-5705)
- Christina Thobakgale (ORCID: https://orcid.org/0000-0001-5619-8894)
- Nikayla Batohi (ORCID: https://orcid.org/0000-0001-6669-3952)
- Sharen Shalekoff
- Caroline T. Tiemessen
- Osman Ebrahim
Institutions
- National Health Laboratory Service (ZA)
- South African Medical Research Council (ZA)
- University of the Witwatersrand (ZA)
- Chris Hani Baragwanath Hospital (ZA)
- Perinatal HIV Research Unit (ZA)
Publication Details
- Journal
- JAIDS Journal of Acquired Immune Deficiency Syndromes
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1097/qai.0000000000003518
- Citations
- 6
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.76
Funders
- European Commission
- National Research Foundation
- South African Medical Research Council
- Poliomyelitis Research Foundation
- Medical Research Council
- European and Developing Countries Clinical Trials Partnership