A PRDM16-driven signal regulates body composition in testosterone-treated hypogonadal men
Our study supports that molecular shift from the adipogenic to the myogenic pathway in men with hypogonadism treated with T could be mediated directly or indirectly by enhanced PRDM16 activity, in turn a result from increased estradiol level. This might have led to the reduction in body fat and increase in lean mass commonly seen in hypogonadal men treated with T.
Authors
- Dennis T. Villareal (ORCID: https://orcid.org/0000-0003-1365-7960)
- Reina Armamento‐Villareal (ORCID: https://orcid.org/0000-0002-5956-4922)
- Lina Aguirre (ORCID: https://orcid.org/0000-0002-5717-3776)
- Siresha Bathina (ORCID: https://orcid.org/0000-0002-1092-5600)
- Georgia Colleluori (ORCID: https://orcid.org/0000-0002-4908-9873)
- Rui Chen (ORCID: https://orcid.org/0000-0002-7026-2247)
Institutions
- Michael E. DeBakey VA Medical Center (US)
- University of New Mexico (US)
- Baylor College of Medicine (US)
- New Mexico VA Health Care System (US)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-09-02
- DOI
- https://doi.org/10.3389/fendo.2024.1426175
- Citations
- 2
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.65
Funders
- National Institute for Health and Care Research
- National Institutes of Health