Inhibition of ADAM17 increases the cytotoxic effect of cisplatin in cervical spheroids and organoids
As two- and three-dimensional models of the same cell lines differ in their responses to chemotherapy it is essential to validate treatment strategies in more advanced model systems representing the patient situation more realistically. Ectocervical organoids showed reliable results regarding treatment responses closely mimicking the primary tumours and could therefore serve as an important tool for personalized medicine in cervical cancer. These findings strengthen the role of ADAM17 as a potential novel target for combinatorial treatments to overcome chemoresistance in cervical cancer.
Authors
- Christoph Rogmans (ORCID: https://orcid.org/0000-0001-9932-0052)
- D Holthaus (ORCID: https://orcid.org/0000-0002-7012-5605)
- Mandy Mangler (ORCID: https://orcid.org/0000-0003-0874-5376)
- Alvaro Quevedo-Olmos (ORCID: https://orcid.org/0000-0002-4137-7045)
- Jörg Weimer (ORCID: https://orcid.org/0000-0002-4528-8509)
- Nina Hedemann (ORCID: https://orcid.org/0000-0002-8222-1063)
- Marzieh Ehsani (ORCID: https://orcid.org/0009-0007-4412-7846)
- Thomas F. Meyer (ORCID: https://orcid.org/0000-0002-6120-8679)
- Dirk Bauerschlag (ORCID: https://orcid.org/0000-0001-8157-6121)
- Nicolaì Maass (ORCID: https://orcid.org/0000-0002-1430-4676)
- Inken Flörkemeier (ORCID: https://orcid.org/0000-0001-5885-6352)
- Ina Gursinski
Institutions
- Christian-Albrechts-Universität zu Kiel (DE)
- Auguste-Viktoria-Klinik (DE)
- University Hospital Schleswig-Holstein (DE)
- Jena University Hospital (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-09-02
- DOI
- https://doi.org/10.3389/fonc.2024.1432239
- Citations
- 5
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.41