Schwann cell-derived exosomes ameliorate peripheral neuropathy induced by ablation of dicer in Schwann cells
This study demonstrates that exogenous SC-Exo ameliorate peripheral neuropathy induced by Dicer ablation in PLP expressing SCs. The therapeutic benefit may be mediated by the SC-Exo altered miRNAs and their targeted genes.
Authors
- Michael Chopp (ORCID: https://orcid.org/0000-0002-1948-4493)
- Brianna Powell
- Zheng Gang Zhang
- William Golembieski
- XueRong Lu
- Alexandra Szalad
- Xian Shuang Liu
- Mei Lü (ORCID: https://orcid.org/0000-0002-3313-6428)
- Lei Wang (ORCID: https://orcid.org/0000-0003-1405-9815)
- Xiaodong Wang (ORCID: https://orcid.org/0000-0002-1045-583X)
- Mikkala Mccann
- Yi Zhang (ORCID: https://orcid.org/0000-0001-6223-4724)
Institutions
- Oakland University (US)
- Henry Ford Hospital (US)
Publication Details
- Journal
- Frontiers in Cellular Neuroscience
- Published
- 2024-09-02
- DOI
- https://doi.org/10.3389/fncel.2024.1462228
- Citations
- 10
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.34
Funders
- National Institute of Diabetes and Digestive and Kidney Diseases