Exploiting branched-chain amino acid metabolism and NOTCH3 expression to predict and target colorectal cancer progression
The BRS is instrumental in predicting the prognosis and therapeutic response in COAD, with NOTCH3 playing a significant role in the proliferation, invasion and migration of COAD. These findings suggest that targeting BCAA metabolism and NOTCH3 could advance COAD treatment strategies.
Authors
- Guozhong Yao
- Shuqing Cao (ORCID: https://orcid.org/0000-0001-6693-877X)
- Xinyi Zhou (ORCID: https://orcid.org/0000-0002-2862-7476)
- P. Li (ORCID: https://orcid.org/0009-0005-7211-7472)
- Kuan Shen
- Chuming Zhu
- Yan Jiang (ORCID: https://orcid.org/0000-0002-1945-4200)
- Jianjun Wu (ORCID: https://orcid.org/0000-0003-4717-3075)
Institutions
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-02
- DOI
- https://doi.org/10.3389/fimmu.2024.1430352
- Citations
- 4
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.14