Role of myeloid cells in mediating the effects of lipids on ulcerative colitis
Our findings elucidate the causal effect of lipids on UC and identify the significant mediating role of myeloid cells CD11b on CD33+ HLA DR+ CD14dim in regulating UC through PC (16:0_0:0), offering new pathways and strategies for UC clinical treatment.
Authors
- Keya Li (ORCID: https://orcid.org/0000-0002-9248-8319)
- Jinyin Xiao
- Wenhong Lu (ORCID: https://orcid.org/0009-0001-4750-2783)
- Xiajun Guo (ORCID: https://orcid.org/0009-0003-7933-0976)
- Zhenquan Wang (ORCID: https://orcid.org/0000-0002-7924-060X)
- Youwei Lin (ORCID: https://orcid.org/0000-0001-7561-5577)
- Wenpeng Luo
Institutions
- Hunan University of Traditional Chinese Medicine (CN)
- Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine (CN)
- Xiang Yang No.1 People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-02
- DOI
- https://doi.org/10.3389/fimmu.2024.1416562
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province