A cheminformatics and network pharmacology approach to elucidate the mechanism of action of Mycobacterium tuberculosis γ-carbonic anhydrase inhibitors
The molecular relationship and pathways linked to the mentioned compounds give the study a holistic perspective of targeting Mtb, which is essential in designing specific therapeutic approaches. Subsequent research will involve experimental validation to demonstrate the efficacy of the promising candidates in Mtb infections.
Authors
- Ashok Aspatwar (ORCID: https://orcid.org/0000-0002-6938-7835)
- Rajarshi Ray (ORCID: https://orcid.org/0000-0001-8633-7808)
- Claudiu T. Supuran (ORCID: https://orcid.org/0000-0003-4262-0323)
- Seppo Parkkila (ORCID: https://orcid.org/0000-0001-7323-8536)
- Kunal Bhattacharya (ORCID: https://orcid.org/0000-0002-5546-1504)
- Ratul Bhowmik (ORCID: https://orcid.org/0000-0002-7013-7323)
- Ajay Manaithiya (ORCID: https://orcid.org/0000-0001-5220-2606)
- Fabrizio Carta (ORCID: https://orcid.org/0000-0002-1141-6146)
- Sagar Singh Shyamal (ORCID: https://orcid.org/0000-0002-8849-6199)
Institutions
- Tampere University (FI)
- Tampere University Hospital (FI)
- Tampere University (FI)
- Fimlab (Finland) (FI)
- National Institute of Pharmaceutical Education and Research (IN)
- Pratiksha Institute of Pharmaceutical Sciences
- University of Florence (IT)
- Banaras Hindu University (IN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-09-02
- DOI
- https://doi.org/10.3389/fphar.2024.1457012
- Citations
- 7
- Primary Topic
- Enzyme function and inhibition
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- Suomen Kulttuurirahasto
- Jane ja Aatos Erkon Säätiö
- Tampereen Tuberkuloosisäätiö