212. CLINICAL RESULTS OF PHOTODYNAMIC THERAPY FOR ESOPHAGEAL CANCER PATIENTS WITH INOPERABLE CONDITION

Abstract Background Although surgical resection is the best way for curing cancer, there has been a certain portion of patients who could not undergo surgery because of various reasons. We experienced 10 cases of photodynamic therapy for esophageal cancer patients (Including one case of carcinoma in-situ) with inoperable conditions, and investigated the feasibility and safety of photodynamic therapy (PDT). Methods Medical records of patients of esophageal cancers who received photodynamic therapies between 2005 and 2022 in our institute were reviewed retrospectively. Survival, complication rates and treatment results were evaluated. Results Average age at the time of treatment was 72.4 (±6.47, ranging 64 to 86) and average follow-up periods were 25.0 (±27.7, ranging 3.8 to 89.8). The average Charlson Comorbidity Index (CCI) were 7.3 (±2.29, ranging 4 to 10). During the follow-up periods, 5 patients died, and only one death was related with the esophageal cancer progression. There was one case of skin reaction and no other complications were appeared. There were no complication related deaths. Complete remission of esophageal cancer showed in 7 patients (70.0%) and partial remission showed in 3 patients (30.0%). Two patients with partial remission showed loco-recurrence. One patient with complete remission had to undergo surgery because of preexisting esophageal stenosis. Conclusion Photodynamic therapy could be an option of palliative therapy for advanced esophageal cancer with reasonable complication rates. Therapeutic application could be considered in early esophageal cancer, especially for patients with poor general condition or refusal of surgery. It was still in debates whether it could substitute the surgical role in early esophageal cancers.