Clinical aPDT's effect on Candida albicans: Antifungal susceptibility, virulence gene expression, and correlation with leukocyte and neutrophil counts
aPDT effectively reduces MICs of antifungal drugs against C. albicans isolated from treated patients, particularly after the first treatment. The concentration of MB required to reduce MICs varies among different antifungal drugs. aPDT does not alter CAT1 or HWP1 expression, and its clinical efficacy in eradicating C. albicans is negatively associated with leukocyte and neutrophil levels.
Authors
- Michael R. Hamblin (ORCID: https://orcid.org/0000-0001-6431-4605)
- Liyi Huang (ORCID: https://orcid.org/0000-0003-2121-1010)
- Meixia Du (ORCID: https://orcid.org/0000-0003-3609-1269)
- Weijun Xuan
Institutions
- Guangxi University (CN)
- Guangxi Medical University (CN)
- University of Johannesburg (ZA)
- Guangxi University of Chinese Medicine (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Photodiagnosis and Photodynamic Therapy
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1016/j.pdpdt.2024.104327
- Citations
- 3
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangxi Province
- Scientific Research and Technology Development Program of Guangxi
- National Institutes of Health