Natural products‐based antiangiogenic agents: New frontiers in cancer therapy
Abstract Angiogenesis, vital for tumor growth and metastasis, is a promising target in cancer therapy. Natural compounds offer potential as antiangiogenic agents with reduced toxicity. This review provides a comprehensive overview of natural product‐based antiangiogenic therapies, focusing on molecular mechanisms and therapeutic potential. A systematic search identified relevant articles from 2019 to 2023. Various natural compounds, including polyphenols, terpenes, alkaloids, cannabinoids, omega‐3 fatty acids, polysaccharides, proteins, and carotenoids, were investigated for their antiangiogenic properties. Challenges such as dose standardization, routes of administration, and potential side effects remain. Further studies, including in‐depth animal models and human epidemiological studies, must elucidate clinical efficacy and safety. Synergistic effects with current antiangiogenic therapies, such as bevacizumab and tyrosine kinase inhibitors, should be explored. Additionally, the potential hormone‐dependent effects of compounds like genistein highlight the need for safety evaluation. In conclusion, natural products hold promise as adjunctive therapies to conventional antineoplastic drugs in modulating angiogenesis in cancer. However, robust clinical trials are needed to validate preclinical findings and ensure safety and efficacy.
Authors
- Tiago Ferreira (ORCID: https://orcid.org/0000-0002-6652-9770)
- Daniela Călina (ORCID: https://orcid.org/0000-0002-1523-9116)
- Dietrich Büsselberg (ORCID: https://orcid.org/0000-0001-5196-3366)
- Hernán Cortés (ORCID: https://orcid.org/0000-0002-6147-4109)
- Rui M. Gil da Costa (ORCID: https://orcid.org/0000-0002-2151-2449)
- Rita Silva‐Reis (ORCID: https://orcid.org/0000-0002-2463-5655)
- Tiago Azevedo (ORCID: https://orcid.org/0000-0002-3030-4510)
- Gerardo Leyva‐Gómez (ORCID: https://orcid.org/0000-0002-7940-1100)
- Javad Sharifi‐Rad (ORCID: https://orcid.org/0000-0002-7301-8151)
- Ana I. Faustino‐Rocha (ORCID: https://orcid.org/0000-0001-5572-6317)
- William Chi Shing Cho (ORCID: https://orcid.org/0000-0003-4174-4586)
- Paula A. Oliveira (ORCID: https://orcid.org/0000-0001-9519-4044)
- Susana M. Cardoso (ORCID: https://orcid.org/0000-0002-7882-737X)
- Sheila I. Peña‐Corona (ORCID: https://orcid.org/0000-0003-2982-1315)
Institutions
- University of Trás-os-Montes and Alto Douro (PT)
- Universidade do Porto (PT)
- Korea University (KR)
- University of Évora (PT)
- University of Medicine and Pharmacy of Craiova (RO)
- Instituto Português de Oncologia Francisco Gentil (PT)
- IPO Porto (PT)
- Instituto Nacional de Rehabilitación (MX)
- Universidad del Azuay (EC)
- Hospital Universitário da Universidade Federal do Maranhão (BR)
- Rede de Química e Tecnologia (PT)
- Weill Cornell Medical College in Qatar (QA)
- Centro de Estudios Tecnológicos y Universitarios del Golfo (MX)
- Queen Elizabeth Hospital (CN)
- Universidade Federal do Maranhão (BR)
- University of Aveiro (PT)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Food Frontiers
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1002/fft2.466
- Citations
- 14
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.27
Funders
- Ministério da Ciência, Tecnologia e Ensino Superior
- Rede de Química e Tecnologia
- Laboratório Associado para a Química Verde
- Fundação para a Ciência e a Tecnologia
- Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México