Unraveling novel mutation patterns and morphological variations in two dalbavancin-resistant MRSA strains in Austria using whole genome sequencing and transmission electron microscopy
In light of increasing vancomycin resistance reports, continuous surveillance is essential to comprehend the molecular mechanisms of resistance in alternative MRSA treatment options. In this work, two novel missense mutations (p.I515M and p.A606D) in the pbp2 gene were newly identified as possible causes of dalbavancin resistance.
Authors
- Michael Ramharter (ORCID: https://orcid.org/0000-0002-9259-1885)
- Katharina Schefberger (ORCID: https://orcid.org/0000-0003-2890-9366)
- M Staudacher (ORCID: https://orcid.org/0009-0007-0348-5030)
- Jürgen Benjamin Hagemann
- Norbert Cyran (ORCID: https://orcid.org/0000-0001-6874-862X)
- Kathrin Spettel (ORCID: https://orcid.org/0000-0002-8901-8770)
- Heinz Burgmann (ORCID: https://orcid.org/0000-0002-2114-0999)
- Katharina Schmid (ORCID: https://orcid.org/0000-0001-6018-9245)
- Felix Lötsch (ORCID: https://orcid.org/0000-0002-6938-9523)
- Katy Schmidt (ORCID: https://orcid.org/0000-0003-4727-8854)
- Heimo Lagler (ORCID: https://orcid.org/0000-0003-3240-7385)
- Julian Frederic Hotz (ORCID: https://orcid.org/0000-0003-0270-790X)
- Richard Kriz (ORCID: https://orcid.org/0000-0002-7388-2927)
- Lisa Schneider (ORCID: https://orcid.org/0000-0002-8928-4702)
- Amelie Leutzendorff
- Simon Daller
- Peter Starzengrüber
Institutions
- St. John's Hospital (US)
- University of Vienna (AT)
- Universität Hamburg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Institute of Medical Microbiology and Hygiene (DE)
- Lenzing (Austria) (AT)
- University Hospital Ulm (DE)
- Medical University of Vienna (AT)
- Bernhard Nocht Institute for Tropical Medicine (DE)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1186/s12879-024-09797-w
- Citations
- 3
- Primary Topic
- Plant Pathogenic Bacteria Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.80