Duropathy as a rare motor neuron disease mimic: from bibrachial amyotrophy to infratentorial superficial siderosis

Based on the long-term follow-up, we could establish that, while the evidence of the VLISFC was concomitant with the clinical presentation of upper limb amyotrophy and weakness, the radiological signs of SS appeared later. This suggests that SS was not per se the cause of the ALS-like clinical picture, but rather a long-term sequela of a dural leak. The latter was instead the causative lesion, giving rise to a VLISFC which compressed the cervical motor roots. Dural tears can actually cause several symptoms, and further studies are needed to elucidate the pathophysiological correlates of "duropathies". Finally, as iron metabolism has been implicated in PD, the co-occurrence of PD with SS deserves further investigation.

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Publication Details

Journal
BMC Neurology
Published
2024-09-02
DOI
https://doi.org/10.1186/s12883-024-03799-6
Citations
2
Primary Topic
Intracerebral and Subarachnoid Hemorrhage Research
Type
article
Field-Weighted Citation Impact
0.74

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article

Duropathy as a rare motor neuron disease mimic: from bibrachial amyotrophy to infratentorial superficial siderosis

Alessandro Sillani, E. Corsini, Viktoriia Iakovleva, Claudia Cinnante et al.
2 citations
BMC Neurology
Intracerebral and Subarachnoid Hemorrhage Research
0.74
article

Duropathy as a rare motor neuron disease mimic: from bibrachial amyotrophy to infratentorial superficial siderosis

Alessandro Sillani, E. Corsini, Viktoriia Iakovleva, Claudia Cinnante, Vincenzo Silani, Emilio Ciusani, Nicola Ticozzi, Alessandra Erbetta, Federico Verde, Giorgio Conte
article en
2 citations

Abstract

Based on the long-term follow-up, we could establish that, while the evidence of the VLISFC was concomitant with the clinical presentation of upper limb amyotrophy and weakness, the radiological signs of SS appeared later. This suggests that SS was not per se the cause of the ALS-like clinical picture, but rather a long-term sequela of a dural leak. The latter was instead the causative lesion, giving rise to a VLISFC which compressed the cervical motor roots. Dural tears can actually cause several symptoms, and further studies are needed to elucidate the pathophysiological correlates of "duropathies". Finally, as iron metabolism has been implicated in PD, the co-occurrence of PD with SS deserves further investigation.

BMC NeurologyVol. 24(1)
University of Milan (IT), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT), IRCCS Istituto Auxologico Italiano (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT), Ferrari (Italy) (IT), Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
Università degli Studi di Milano, Dipartimenti di Eccellenza, Ministero della Salute, Istituto Auxologico Italiano
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Intracerebral and Subarachnoid Hemorrhage Research
0.74
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