Heterocycle-guided synthesis of <i>m</i>-hetarylanilines via three-component benzannulation
A one-pot three-component synthesis of substituted <i>meta</i>-hetarylanilines from heterocycle-substituted 1,3-diketones has been developed. The electron-withdrawing power of the heterocyclic substituent (which can be estimated on the basis of calculated Hammett constants) in the 1,3-diketone plays a pivotal role in the studied reaction. The series of <i>meta</i>-hetarylanilines prepared (21-85% isolated yield) demonstrates the synthetic utility of the developed method.
Authors
- Andrew R. Galeev (ORCID: https://orcid.org/0000-0002-8887-7899)
- А. Н. Масливец (ORCID: https://orcid.org/0000-0001-7148-4450)
- Alexander S. Novikov (ORCID: https://orcid.org/0000-0001-9913-5324)
- М. В. Дмитриев (ORCID: https://orcid.org/0000-0002-8817-0543)
Institutions
- Perm State University (RU)
- Peoples' Friendship University of Russia (RU)
- St Petersburg University (RU)
Publication Details
- Journal
- Beilstein Journal of Organic Chemistry
- Published
- 2024-09-02
- DOI
- https://doi.org/10.3762/bjoc.20.188
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Science and Higher Education of the Russian Federation
- RUDN University