Inhibiting histone deacetylase 6 suppresses the proliferation of microvascular endothelial cells by epigenetically activating miR-375-3p, potentially contributing to bone loss during mechanical unloading
Our study revealed that disuse-induced bone loss may be closely related to a reduction in the number of bone microvessels and that the modulation of MVEC function could improve bone loss induced by unloading. Mechanistically, the HDAC6/miR-375-3p/LRP5 pathway in MVECs might be a promising strategy for the clinical treatment of unloading-induced bone loss.
Authors
- Zebing Hu
- Gaozhi Li
- Xinsheng Cao (ORCID: https://orcid.org/0009-0004-7444-3039)
- Quan Sun (ORCID: https://orcid.org/0009-0004-3861-3416)
- Yixuan Wang (ORCID: https://orcid.org/0000-0002-7436-1429)
- Shu Zhang (ORCID: https://orcid.org/0000-0002-4380-1268)
- Liqun Xu (ORCID: https://orcid.org/0000-0002-2759-0077)
- Fei Shi (ORCID: https://orcid.org/0000-0003-2596-6955)
- Xiaoyan Zhang (ORCID: https://orcid.org/0000-0001-6892-1082)
- Lijun Zhang (ORCID: https://orcid.org/0000-0003-4974-2745)
Institutions
- 82th Hospital of Pla (CN)
- Bethune International Peace Hospital (CN)
- Air Force General Hospital PLA (CN)
- Anyang Hospital of Traditional Chinese Medicine (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1186/s12967-024-05608-7
- Citations
- 2
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- National Natural Science Foundation of China