Combination of arsenic trioxide and apatinib synergistically inhibits small cell lung cancer by down-regulating VEGFR2/mTOR and Akt/c-Myc signaling pathway via GRB10
Synergistically, ATO and APA have a more significant impact on inhibiting cell proliferation than each drug independently. ATO and APA may be mediating its action through the stabilization of GRB10 thus acting as a tumor suppressor. We thus, preliminarily report the impact of GRB10 stability as a target for SCLC treatment.
Authors
- Wenchao Shi
- Qi Wang (ORCID: https://orcid.org/0000-0003-0858-9393)
- Ce Shi (ORCID: https://orcid.org/0000-0002-1033-1626)
- Yu Yao (ORCID: https://orcid.org/0000-0002-8366-4712)
- Si Shi (ORCID: https://orcid.org/0000-0002-6652-0629)
- Hong Chen (ORCID: https://orcid.org/0000-0002-8146-0943)
- Yu Shang
- Dandan Xu (ORCID: https://orcid.org/0000-0003-2798-8349)
- Yaowu He (ORCID: https://orcid.org/0000-0002-7828-263X)
- Menghan Wang (ORCID: https://orcid.org/0009-0001-0850-919X)
Institutions
- Harbin Medical University (CN)
- The First Hospital of Kunming (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
- Heilongjiang Provincial Hospital (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Hereditas
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1186/s41065-024-00330-2
- Citations
- 4
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.13
Funders
- Harbin Medical University
- Wu Jieping Medical Foundation