Targeting NLRP3 inhibits AML progression by inducing PERK/eIF2-mediated apoptosis
Our findings elucidate the involvement of the NLRP3/PERK/eIF2 axis as a novel driver of AML cell survival. Targeting NLRP3-induced signaling pathways, particularly through the PERK/eIF2 axis, presents a promising therapeutic strategy for AML intervention. These insights into the role of the NLRP3 inflammasome offer potential avenues for improving the prognosis and treatment outcomes of AML patients.
Authors
- Daniel Neureiter (ORCID: https://orcid.org/0000-0001-9155-5762)
- Dirk Schmidt‐Arras (ORCID: https://orcid.org/0000-0002-1072-7495)
- Michael Stefan Unger (ORCID: https://orcid.org/0000-0002-8677-0983)
- Philip Steiner (ORCID: https://orcid.org/0000-0003-3586-4231)
- Julia Vetter (ORCID: https://orcid.org/0000-0002-9169-3935)
- Dirk Strunk (ORCID: https://orcid.org/0000-0003-1810-867X)
- Richard Greil
- Fritz Aberger (ORCID: https://orcid.org/0000-0003-2009-6305)
- Helene Sieberer
- Susanne Schaller
- Helen Strandt (ORCID: https://orcid.org/0000-0002-1488-1633)
- Constantin Blöchl (ORCID: https://orcid.org/0000-0003-3406-4232)
- Stephan Winkler (ORCID: https://orcid.org/0000-0002-5196-4294)
- Tanja Nicole Hartmann (ORCID: https://orcid.org/0000-0002-0377-7179)
- Christian X. Weichenberger (ORCID: https://orcid.org/0000-0002-2176-0274)
- Lisa Pleyer (ORCID: https://orcid.org/0000-0002-2790-5067)
- Jutta Horejs‐Hoeck (ORCID: https://orcid.org/0000-0002-0984-204X)
- Ancuela Andosch
- Suzana Tesanovic
- Theresa Neuper (ORCID: https://orcid.org/0000-0001-9801-2226)
- Diana Amend
- Dominik P. Elmer (ORCID: https://orcid.org/0000-0003-2038-6775)
- Hieu-Hoa Dang
- Michela Luciano
- Peter W. Krenn (ORCID: https://orcid.org/0000-0002-8896-8387)
- Christian G. Huber
- Anna Eglseer
- Laura Hummer
- Stephanie Binder
- Renate Bauer (ORCID: https://orcid.org/0009-0009-7109-6656)
Institutions
- Johannes Kepler University of Linz (AT)
- Eurac Research (IT)
- University of Freiburg (DE)
- University of Salzburg (AT)
- Paracelsus Medical University (AT)
- University Medical Center Freiburg (DE)
- Institute for Biomedicine (IT)
- University of Applied Sciences Upper Austria (AT)
- Unfallkrankenhaus Salzburg (AT)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1186/s12964-024-01777-6
- Citations
- 8
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Austrian Science Fund
- Universität Salzburg
- José Carreras Leukämie-Stiftung
- Salzburger Landesregierung
- Interreg