Asthma development is associated with low mucosal <scp>IL</scp>‐10 during viral infections in early life
We described the airway immune mediator profile during viral respiratory illnesses in early life and showed that children developing asthma by age 6 years have a reduced regulatory (IL-10) immune mediator level. This provides insight into the interplay between early-life viral infections, airway immunity and asthma development.
Authors
- Jonathan Thorsen (ORCID: https://orcid.org/0000-0003-0200-0461)
- Klaus Bønnelykke (ORCID: https://orcid.org/0000-0003-2003-1018)
- Bo Chawes (ORCID: https://orcid.org/0000-0001-6846-6243)
- Ann‐Marie Malby Schoos (ORCID: https://orcid.org/0000-0002-5827-0885)
- James E. Gern (ORCID: https://orcid.org/0000-0002-6667-4708)
- Marianne Mikkelsen (ORCID: https://orcid.org/0000-0002-1047-1549)
- Signe Kjeldgaard Jensen (ORCID: https://orcid.org/0000-0002-3375-6555)
- Jakob Stokholm (ORCID: https://orcid.org/0000-0003-4989-9769)
- Anders Eliasen (ORCID: https://orcid.org/0000-0003-2629-0790)
- Casper‐Emil Tingskov Pedersen (ORCID: https://orcid.org/0000-0003-2540-5373)
- Mathias Elsner Melgaard (ORCID: https://orcid.org/0009-0003-1663-7137)
- Susanne Brix (ORCID: https://orcid.org/0000-0001-8951-6705)
- Nilofar Vahman
Institutions
- University of Copenhagen (DK)
- University of Wisconsin–Madison (US)
- Gentofte Hospital (DK)
- Slagelse Hospital (DK)
- Copenhagen Prospective Studies on Asthma in Childhood (DK)
- Wisconsin Division of Public Health (US)
- Technical University of Denmark (DK)
Publication Details
- Journal
- Allergy
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1111/all.16276
- Citations
- 8
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.61
Funders
- Strategiske Forskningsråd
- Lundbeckfonden
- Region Hovedstaden
- Ministeriet Sundhed Forebyggelse
- Novo Nordisk Fonden