Development of a large diameter in vitro flow loop thrombogenicity test system
The 9.5 -mm ID test system can effectively differentiate materials of varying thrombogenic potentials when appropriate pump occlusion settings and donor-specific anticoagulation are used. This system is being assessed in an interlaboratory study to develop standardized best practices for performing in vitro dynamic thrombogenicity testing of medical devices and materials.
Authors
- Qijin Lu (ORCID: https://orcid.org/0000-0002-3004-9433)
- Richard A. Malinauskas (ORCID: https://orcid.org/0000-0002-5298-4502)
- Mehulkumar Patel (ORCID: https://orcid.org/0000-0002-0218-593X)
- Keerthana Srinivasan
- Megan A. Jamiolkowski (ORCID: https://orcid.org/0000-0002-5447-5621)
- Anna Parrish
- Carlos J. Serna
Institutions
- United States Food and Drug Administration (US)
- Center for Devices and Radiological Health (US)
Publication Details
- Journal
- Artificial Organs
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1111/aor.14852
- Primary Topic
- Venous Thromboembolism Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Energy
- U.S. Food and Drug Administration
- Oak Ridge Institute for Science and Education