METTL16-SENP3-LTF axis confers ferroptosis resistance and facilitates tumorigenesis in hepatocellular carcinoma
Our study reveals a new METTL16-SENP3-LTF signaling axis regulating ferroptosis and driving HCC development. Targeting this axis is a promising strategy for sensitizing ferroptosis and against HCC.
Authors
- Yong Gao
- Mengxi Xiu
- Jialin Wang (ORCID: https://orcid.org/0000-0001-7877-1620)
- Yandong Li (ORCID: https://orcid.org/0000-0001-8153-081X)
- Jin Wang (ORCID: https://orcid.org/0009-0002-4560-8231)
Institutions
- Shanghai East Hospital (CN)
Publication Details
- Journal
- Journal of Hematology & Oncology
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1186/s13045-024-01599-6
- Citations
- 50
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 11.69
Funders
- National Natural Science Foundation of China