Mavacamten-Associated Temporal Changes in Left Atrial Function in Obstructive HCM
In VALOR-HCM, mavacamten resulted in an improvement in LAVI and LA strain at week 56, suggesting sustained favorable LA remodeling and improved function, except in the atrial fibrillation subgroup. Whether the advantageous LA remodeling associated with long-term treatment with mavacamten results in a favorable impact on the observed high burden of atrial tachyarrhythmias in HCM remains to be proven. (A Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy Who Are Eligible for Septal Reduction Therapy [VALOR-HCM]; NCT04349072).
Authors
- Pietro Bajona
- Jeffrey Benjamin Geske (ORCID: https://orcid.org/0000-0003-1671-4262)
- Zoran Popović (ORCID: https://orcid.org/0000-0001-5692-2299)
- Kathy Lampl
- John C. Stendahl (ORCID: https://orcid.org/0000-0002-1568-9280)
- R. Bach
- J. Orford (ORCID: https://orcid.org/0000-0003-0856-783X)
- David Fermin (ORCID: https://orcid.org/0009-0000-1118-6718)
- Paul C Cremer (ORCID: https://orcid.org/0000-0002-0794-3306)
- Sara Saberi (ORCID: https://orcid.org/0000-0003-4473-6725)
- Milind Y. Desai (ORCID: https://orcid.org/0000-0003-0010-9797)
- Amy J. Sehnert (ORCID: https://orcid.org/0000-0003-1912-1710)
- Suveeksha Naidu
- ANJALI TIKU OWENS (ORCID: https://orcid.org/0000-0002-9669-8495)
- Steven E. Nissen (ORCID: https://orcid.org/0000-0002-7231-6464)
- Andrew Z. Wang (ORCID: https://orcid.org/0000-0002-9781-4494)
- M. Zenker
- Albree Tower‐Rader
- Mark V. Sherrid (ORCID: https://orcid.org/0000-0003-4972-7780)
- Neal K. Lakdawala (ORCID: https://orcid.org/0000-0001-6458-5421)
- Matthew Thomas Wheeler (ORCID: https://orcid.org/0000-0001-8721-3022)
- Srihari S. Naidu (ORCID: https://orcid.org/0000-0003-4073-5143)
- Ahmad Masri (ORCID: https://orcid.org/0000-0002-6390-6526)
- Florian Rader (ORCID: https://orcid.org/0000-0003-1637-5096)
- Yuichiro Okushi (ORCID: https://orcid.org/0009-0004-8534-6760)
- Andrew Wang (ORCID: https://orcid.org/0000-0001-8729-0933)
- Kathy Wolski
- Neal K. Lakdawala
Institutions
- Cleveland Clinic (US)
- Westchester Medical Center (US)
- Mayo Clinic (US)
- Duke University (US)
- University of Michigan (US)
- Bristol-Myers Squibb (United States) (US)
- Trinity Health Grand Rapids (US)
- Center for Clinical Research (United States) (US)
- Corewell Health
- Mass General Brigham (US)
- New York University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- JACC. Cardiovascular imaging
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1016/j.jcmg.2024.08.005
- Citations
- 32
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 12.87
Funders
- Bristol-Myers Squibb
- Celgene