528. IMPACT OF SARCOPENIA AND MYOSTEATOSIS ON THE SURGICAL OUTCOME OF PATIENTS WITH ESOPHAGEAL CANCER

Abstract Background Alterations in muscle mass, sarcopenia and myosteatosis might negatively affect the surgical outcome of patients with cancer. Body composition correlation with biochemical markers and impact on surgical outcome in esophageal cancers is yet to be fully determined. Study design Patients with esophageal and esophageal-gastric junction cancer undergoing resection with curative intent were enrolled in a prospective clinical trial from to 2019 to 2023. Patients were assessed at presentation for anthropometric measures, past medical history and biohumoral markers. Contrast-enhanced CT-scans were used to analyze body composition and to detect low lumbar skeletal muscle index (SMI) and low mean muscle attenuation. We investigated the association between the presence of sarcopenia and/or myosteatosis and malnutrition or systemic inflammatory state. Results We enrolled 130 esophagogastric cancer patients who underwent Ivor-Lewis esophagectomy. Postoperative morbidity was not significantly higher in the sarcopenic group compared to non-sarcopenic patients (p=0.35). Myosteatosis and albumin level weren’t associated with post-operative morbidity (p=0.11). No differences in overall survival were found in patients with myosteatosis or sarcopenia compared to subjects with normal body composition (p=0.12 and p=0.16). Conclusion Our preliminary data shows no significant correlations between sarcopenia and myosteatosis and postoperative outcome and survival following esophagectomy for esophageal cancer. These findings from an high volume center suggest that factors other than these body composition parameters may play a more significant role in determining postoperative outcomes in patients undergoing esophagectomy. Further research is warranted to elucidate additional prognostic indicators and optimize patients care in this population.