Proteomic networks and related genetic variants associated with smoking and chronic obstructive pulmonary disease
In this work, we apply state-of-the-art molecular network generation and summarization approaches to proteomic data from COPDGene participants to uncover protein networks associated with COPD phenotypes. We further identify genetic associations with networks. This work discovers protein networks containing known and novel proteins and protein interactions associated with clinically relevant COPD phenotypes across race groups and cohorts.
Authors
- Farnoush Banaei‐Kashani (ORCID: https://orcid.org/0000-0003-4102-9873)
- W. M. Liu (ORCID: https://orcid.org/0009-0005-0222-1784)
- Russell Paul Bowler (ORCID: https://orcid.org/0000-0003-4651-363X)
- Michael H. Cho (ORCID: https://orcid.org/0000-0002-4907-1657)
- Katherine Pratte (ORCID: https://orcid.org/0000-0003-3358-8907)
- Katerina Kechris (ORCID: https://orcid.org/0000-0002-3725-5459)
- Ani Manichaikul (ORCID: https://orcid.org/0000-0002-5998-795X)
- Thao Thi Phuong Vu (ORCID: https://orcid.org/0000-0003-3946-6820)
- Elizabeth Litkowski (ORCID: https://orcid.org/0000-0002-7079-696X)
- Dawn L. DeMeo (ORCID: https://orcid.org/0000-0001-9653-0636)
- Luciana B. Vargas (ORCID: https://orcid.org/0000-0002-9074-2010)
- Craig P. Hersh (ORCID: https://orcid.org/0000-0002-1342-4334)
- Iain R. Konigsberg (ORCID: https://orcid.org/0000-0001-7356-100X)
- Mohamed Abdel-Hafiz
- Leslie A. Lange (ORCID: https://orcid.org/0000-0002-4220-6766)
- Niles Gilmore
Institutions
- Brigham and Women's Hospital (US)
- University of Denver (US)
- Harvard University (US)
- Colorado School of Public Health (US)
- University of Michigan (US)
- National Jewish Health (US)
- University of Virginia (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- BMC Genomics
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1186/s12864-024-10619-1
- Citations
- 5
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- COPD Foundation
- Sunovion
- Genentech
- National Heart, Lung, and Blood Institute