Unraveling the Mfn2-Warburg effect nexus: a therapeutic strategy to combat pulmonary arterial hypertension arising from catch-up growth after IUGR
Imbalanced mitochondrial dynamics, characterized by reduced Mfn2 expression, plays a critical role in the development of fetal-originated PAH following postnatal catch-up growth after IUGR. Mfn2 emerges as a promising therapeutic strategy for managing IUGR-catch-up growth induced PAH.
Authors
- Lizhong Du (ORCID: https://orcid.org/0000-0002-3181-810X)
- Ziming Zhang (ORCID: https://orcid.org/0000-0002-8307-2717)
- Chengcheng Hang (ORCID: https://orcid.org/0000-0001-5758-7541)
- Shanshan Xu (ORCID: https://orcid.org/0000-0001-7652-8774)
- Lingling Yan (ORCID: https://orcid.org/0000-0002-2813-5463)
- Xiaofei Luo (ORCID: https://orcid.org/0000-0003-1667-5048)
- YuWang
Institutions
- Children's Hospital of Zhejiang University (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1186/s12931-024-02957-1
- Citations
- 4
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities