Evidence of survival bias in the association between APOE-Є4 and age at ischemic stroke onset
In conclusion, we detected a robust association of the APOE locus with stroke AAO and provided simulations to suggest that this association may be unrelated to ischemic stroke per se but related to a general survival bias.
Authors
- Steven J. Kittner (ORCID: https://orcid.org/0000-0002-8457-8744)
- Paavo Häppölä (ORCID: https://orcid.org/0000-0002-8502-0582)
- Robin Lemmens (ORCID: https://orcid.org/0000-0002-4948-5956)
- Braxton D. Mitchell (ORCID: https://orcid.org/0000-0003-4920-4744)
- Patrick F. McArdle (ORCID: https://orcid.org/0000-0001-6649-0717)
- Vincent Thijs (ORCID: https://orcid.org/0000-0002-6614-8417)
- Joanna von Berg (ORCID: https://orcid.org/0000-0001-7067-1406)
- Sander W. van der Laan (ORCID: https://orcid.org/0000-0001-6888-1404)
- Sara L. Pulit (ORCID: https://orcid.org/0000-0002-2502-3669)
- Jeroen de Ridder (ORCID: https://orcid.org/0000-0002-0828-3477)
- Charles Kooperberg
- Alessandro Pezzini (ORCID: https://orcid.org/0000-0001-8629-3315)
- Jeffrey Haessler
Institutions
- University of Parma (IT)
- University of Maryland, Baltimore (US)
- University of Helsinki (FI)
- The University of Melbourne (AU)
- Utrecht University (NL)
- Florey Institute of Neuroscience and Mental Health (AU)
- University of Virginia Health System (US)
- University Medical Center Utrecht (NL)
- Fred Hutch Cancer Center (US)
- Oncode Institute (NL)
- Institute for Molecular Medicine Finland (FI)
- VA Maryland Health Care System (US)
- Austin Health (AU)
- University of Virginia (US)
- KU Leuven (BE)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2024-09-02
- DOI
- https://doi.org/10.3389/fgene.2024.1392061
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- U.S. Department of Veterans Affairs
- Bristol-Myers Squibb
- Pfizer
- AstraZeneca
- Biogen
- Celgene
- Health~Holland
- Fondation Leducq
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Business Finland
- European Research Area Network on Cardiovascular Diseases
- National Institutes of Health
- Genentech
- Horizon 2020 Framework Programme
- National Heart, Lung, and Blood Institute