Tryptophan 2,3‐dioxygenase‐positive matrix fibroblasts fuel breast cancer lung metastasis via kynurenine‐mediated ferroptosis resistance of metastatic cells and T cell dysfunction
Our study reveals crucial roles of TDO2<sup>+</sup> MFs in promoting lung metastasis and DTCs' immune evasion in the metastatic niche. It suggests that targeting the metabolism of lung-specific stromal cells may be an effective treatment strategy for breast cancer patients with lung metastasis.
Authors
- Manran Liu (ORCID: https://orcid.org/0000-0002-3898-6878)
- Yixuan Hou (ORCID: https://orcid.org/0000-0002-0948-7463)
- Chao Chang (ORCID: https://orcid.org/0000-0002-5844-8014)
- Yubi Gan
- Yuetong Guo (ORCID: https://orcid.org/0009-0007-8744-2547)
- Xueying Wan
- Yongcan Liu (ORCID: https://orcid.org/0009-0001-6698-5282)
- Xiaojiang Cui (ORCID: https://orcid.org/0000-0002-6843-736X)
- Haojun Luo
- Yong Teng (ORCID: https://orcid.org/0000-0002-1856-7289)
- Rui Wang (ORCID: https://orcid.org/0000-0003-2782-7772)
- Yan Sun
- Peijin Dai
- Shan-Chun Chen (ORCID: https://orcid.org/0000-0002-9171-7028)
Institutions
- Cedars-Sinai Medical Center (US)
- Georgia Institute of Technology (US)
- Emory University (US)
- Dalian Medical University (CN)
- The Wallace H. Coulter Department of Biomedical Engineering (US)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Ministry of Education (TH)
- Samueli Institute (US)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Cancer Communications
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1002/cac2.12608
- Citations
- 38
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 8.89
Funders
- National Natural Science Foundation of China