Deubiquitinase USP10 promotes osteosarcoma autophagy and progression through regulating GSK3β-ULK1 axis
Collectively, we demonstrated that the USP10-GSK3β-ULK1 axis promoted autophagy, cell proliferation, and invasion in OS. The findings imply that targeting USP10 may offer a promising therapeutic avenue for treating OS.
Authors
- Minghao Deng
- Xiaohua Yan (ORCID: https://orcid.org/0000-0002-7528-5771)
- Yanghuan Ou
- Xueqiang Deng (ORCID: https://orcid.org/0000-0003-0003-7092)
- Zuxi Feng (ORCID: https://orcid.org/0000-0002-9846-4027)
- Leifeng Chen (ORCID: https://orcid.org/0000-0001-8305-1900)
- Fan Zhou
- Liang Hao
Institutions
- Nanchang University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Cancer Center (US)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Nottingham Trent University (GB)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1186/s13578-024-01291-9
- Citations
- 12
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 4.64
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province
- Nanchang University
- Youth and Middle-aged Scientific and Technological Innovation Leading Talents Program of the Corps