Specific imaging of CD8 + T-Cell dynamics with a nanobody radiotracer against human CD8β
This study describes the development of a more specific human CD8<sup>+</sup> T-cell-targeting immunotracer, allowing follow-up of immunotherapy responses by non-invasive imaging of human CD8<sup>+</sup> T-cell dynamics.
Authors
- Roger Le Grand (ORCID: https://orcid.org/0000-0002-4928-4484)
- Geert Raes (ORCID: https://orcid.org/0000-0002-9065-1549)
- Cécile Vincke (ORCID: https://orcid.org/0000-0003-0681-7444)
- Timo W.M. De Groof (ORCID: https://orcid.org/0000-0001-6918-2955)
- Thibaut Naninck
- Jo A. Van Ginderachter (ORCID: https://orcid.org/0000-0002-4442-7474)
- Yoline Lauwers (ORCID: https://orcid.org/0000-0002-6619-7403)
- Nick Devoogdt (ORCID: https://orcid.org/0000-0001-9220-4833)
- Catherine Chapon (ORCID: https://orcid.org/0000-0002-3210-8468)
- Tessa De Pauw (ORCID: https://orcid.org/0000-0001-7359-1751)
- Jolien Van Craenenbroeck (ORCID: https://orcid.org/0009-0000-1795-3957)
- Mohit Saxena
Institutions
- Vrije Universiteit Brussel (BE)
- Inserm (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- CEA Paris-Saclay (FR)
- Infectious Disease Models and Innovative Therapies (FR)
- VIB-UGent Center for Inflammation Research (BE)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1007/s00259-024-06896-3
- Citations
- 11
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 4.45
Funders
- Agence Nationale de la Recherche
- Fonds Wetenschappelijk Onderzoek
- Horizon 2020