Mucositis with targetoid lesions in an adult
A 34-year-old woman without an autoimmune history was started on lamotrigine 10 days ago for unprovoked seizures.She presents with a 2-day history of Nikolsky-negative violaceous papules and plaques of the malar region (Fig 1,A).There were a few macular and atypical targetoid lesions on the trunk (Fig 1, B andC ).The patient had extensive lip and oral erosions with positive antinuclear antibodies (ANA) (titer of 1:160, speckled pattern) and anti-Sjogren's-syndrome-related antigen A (anti-SSA/Ro) antibodies.Extensive testing for viral and bacterial infections was negative.Lesional skin biopsy revealed pauci-inflammatory interface dermatitis with extensive keratinocyte necrosis with a negative direct immunofluorescence study.Question 1: What is the most likely diagnosis based on the clinical presentation, laboratory studies, and histopathology? A. Stevens-Johnson syndrome (SJS) B. Rowell syndrome C.
Authors
- Jose A. Jaller (ORCID: https://orcid.org/0000-0001-8394-3503)
- Carson Kirkpatrick
- Michelle Toker (ORCID: https://orcid.org/0000-0002-6513-9033)
- Benedict Wu (ORCID: https://orcid.org/0000-0003-4829-5912)
- Daniel R. Antohi (ORCID: https://orcid.org/0009-0006-1823-8457)
- Tian Zhu
Institutions
- Albert Einstein College of Medicine (US)
- Montefiore Medical Center (US)
Publication Details
- Journal
- JAAD Case Reports
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1016/j.jdcr.2024.08.022
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00