Mucositis with targetoid lesions in an adult

A 34-year-old woman without an autoimmune history was started on lamotrigine 10 days ago for unprovoked seizures.She presents with a 2-day history of Nikolsky-negative violaceous papules and plaques of the malar region (Fig 1,A).There were a few macular and atypical targetoid lesions on the trunk (Fig 1, B andC ).The patient had extensive lip and oral erosions with positive antinuclear antibodies (ANA) (titer of 1:160, speckled pattern) and anti-Sjogren's-syndrome-related antigen A (anti-SSA/Ro) antibodies.Extensive testing for viral and bacterial infections was negative.Lesional skin biopsy revealed pauci-inflammatory interface dermatitis with extensive keratinocyte necrosis with a negative direct immunofluorescence study.Question 1: What is the most likely diagnosis based on the clinical presentation, laboratory studies, and histopathology? A. Stevens-Johnson syndrome (SJS) B. Rowell syndrome C.

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Publication Details

Journal
JAAD Case Reports
Published
2024-09-02
DOI
https://doi.org/10.1016/j.jdcr.2024.08.022
Primary Topic
Drug-Induced Adverse Reactions
Type
article
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article

Mucositis with targetoid lesions in an adult

Jose A. Jaller, Carson Kirkpatrick, Michelle Toker, Benedict Wu et al.
JAAD Case Reports
Drug-Induced Adverse Reactions
article

Mucositis with targetoid lesions in an adult

Jose A. Jaller, Carson Kirkpatrick, Michelle Toker, Benedict Wu, Daniel R. Antohi, Tian Zhu
article en

Abstract

A 34-year-old woman without an autoimmune history was started on lamotrigine 10 days ago for unprovoked seizures.She presents with a 2-day history of Nikolsky-negative violaceous papules and plaques of the malar region (Fig 1,A).There were a few macular and atypical targetoid lesions on the trunk (Fig 1, B andC ).The patient had extensive lip and oral erosions with positive antinuclear antibodies (ANA) (titer of 1:160, speckled pattern) and anti-Sjogren's-syndrome-related antigen A (anti-SSA/Ro) antibodies.Extensive testing for viral and bacterial infections was negative.Lesional skin biopsy revealed pauci-inflammatory interface dermatitis with extensive keratinocyte necrosis with a negative direct immunofluorescence study.Question 1: What is the most likely diagnosis based on the clinical presentation, laboratory studies, and histopathology? A. Stevens-Johnson syndrome (SJS) B. Rowell syndrome C.

JAAD Case ReportsVol. 53
Albert Einstein College of Medicine (US), Montefiore Medical Center (US)
Openalex Percentile: Top 86%
Drug-Induced Adverse Reactions
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