Phytochemicals, Two New Sulphur Glycosides and Two New Natural Products, from Shepherd’s Purse Seed and Their Activities
Two new sulfur glycosides, bursapastoris A-B (<b>3</b>-<b>4</b>), were extracted and isolated from shepherd's purse seed, along with two new natural products, 11-(methylsulfinyl)undecanoic acid (<b>2</b>) and 10-(methylsulfinyl)decanoic acid (<b>1</b>). Their structures were determined though infrared spectroscopy, one-dimensional nuclear magnetic resonance (<sup>1</sup>H and <sup>13</sup>C), and electrospray ionization mass spectrometry. Additionally, the structures of <b>3</b>-<b>4</b> were further identified by two-dimensional nuclear magnetic resonance (HMBC, HSQC, <sup>1</sup>H-<sup>1</sup>H COSY, and NOESY). Compounds <b>1</b>-<b>4</b> showed relatively favorable docking to NF-<i>κ</i>B. Unfortunately, we only discovered that compound <b>1</b>-<b>4</b> had weak anti-radiation activity at present. Therefore, further research regarding the biological activity of these organosulfur compounds is required at a later stage.
Authors
- Zhen-Zhen Wei (ORCID: https://orcid.org/0009-0005-3290-9360)
- Ti-Qiang Zhou
- Shu‐Chen Liu (ORCID: https://orcid.org/0000-0001-6959-2495)
- Bin Li (ORCID: https://orcid.org/0000-0001-7763-4245)
- Ying Tian (ORCID: https://orcid.org/0000-0003-3225-7962)
- Chunbo Ge
- Jianfeng Yi (ORCID: https://orcid.org/0000-0003-4274-5871)
- Yujie Wang (ORCID: https://orcid.org/0009-0009-2732-1991)
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Beijing Institute of Technology (CN)
- Hebei University (CN)
Publication Details
- Journal
- Molecules
- Published
- 2024-08-31
- DOI
- https://doi.org/10.3390/molecules29174145
- Citations
- 1
- Primary Topic
- Phytochemicals and Antioxidant Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.22
Funders
- China Postdoctoral Science Foundation
- Jiangxi University of Traditional Chinese Medicine