Rare Genetic Variants in <i>LDLR</i> , <i>APOB</i> , and <i>PCSK9</i> Are Associated With Aortic Stenosis
Rare genetic variants that confer lifelong higher or lower LDL-C levels are associated with substantially increased and decreased risk of AS, respectively. Early and sustained lipid-lowering therapy may slow or prevent AS development.
Authors
- James P. Pirruccello (ORCID: https://orcid.org/0000-0001-6088-4037)
- Shinwan Kany (ORCID: https://orcid.org/0000-0001-8113-733X)
- Shaan Khurshid (ORCID: https://orcid.org/0000-0002-2840-4539)
- Seung Hoan Choi (ORCID: https://orcid.org/0000-0002-2797-3190)
- Joel Rämö (ORCID: https://orcid.org/0000-0002-6429-5149)
- Sam Friedman (ORCID: https://orcid.org/0000-0002-0688-2169)
- Patrick T. Ellinor (ORCID: https://orcid.org/0000-0002-2067-0533)
- Sean J. Jurgens (ORCID: https://orcid.org/0000-0002-1605-9782)
- Mahnaz Maddah (ORCID: https://orcid.org/0000-0002-9837-6000)
- Xin Wang (ORCID: https://orcid.org/0000-0002-0322-8970)
- Andrey N. Smirnov (ORCID: https://orcid.org/0000-0002-4450-0408)
Institutions
- Broad Institute (US)
- Boston University (US)
- Brigham and Women's Hospital (US)
- University of Helsinki (FI)
- Harvard University (US)
- Universität Hamburg (DE)
- University of California, San Francisco (US)
- University of Cambridge (GB)
- Boston Foundation (US)
- Wellcome Sanger Institute (GB)
- World Wide Web Consortium (US)
- Massachusetts General Hospital (US)
- Cancer Research And Biostatistics (US)
- University Medical Center Hamburg-Eppendorf (DE)
- Institute of Human Genetics (PL)
- German Centre for Cardiovascular Research (DE)
- Institute for Molecular Medicine Finland (FI)
- Amsterdam University Medical Centers (NL)
- Jisc (GB)
- University of Amsterdam (NL)
Publication Details
- Journal
- Circulation
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1161/circulationaha.124.070982
- Citations
- 16
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.43
Funders
- American Heart Association
- Bristol-Myers Squibb
- Pfizer
- Bayer
- European Commission
- Deutsche Forschungsgemeinschaft
- Hartstichting
- Novo Nordisk
- Sigrid Juséliuksen Säätiö
- National Institutes of Health