Does low-energy fractional carbon dioxide laser therapy improve hair regrowth in female-pattern hair loss?

Background Female-pattern hair loss (FPHL) has the potential to impact the quality of life, physical attractiveness, and interpersonal relationships of many patients. In recent years, lasers and light therapy have been used as alternatives or supplementary therapy for hair loss. Objective To evaluate the efficacy of ablative fractional carbon dioxide (CO 2 ) laser therapy alone in improving hair growth in FPHL. Patients and methods Thirty patients presenting with FPHL were included in a split-scalp prospective interventional study. Two areas of the scalp were studied. One area was treated with fractional CO 2 laser and the second was injected with intradermal saline as control. The sessions were scheduled every 2 weeks for four sessions then monthly for 2 months. Patients were evaluated after each session and 2 months after the last session. Results were evaluated by clinical photography, trichoscopic, and folliscopic examination regarding the count of terminal and vellus hair, the thickness and density of hair shafts, and the patient’s satisfaction score. Results Fractional CO 2 laser therapy alone was found to be effective in improving hair growth in FPHL. Conclusion Fractional CO 2 laser therapy would have potential mechanisms in inducing hair regrowth in FPHL. However, the detailed mechanisms underlying hair regrowth and injury induced by the laser need further clarification.