Genetic markers of late radiation toxicity in the era of image-guided radiotherapy: lower toxicity rates reduce the predictive value of γ-H2AX foci decay ratio in patients undergoing pelvic radiotherapy
In the present study, the γ-H2AX foci decay ratio could not be validated as a predictor of late radiation toxicity in patients with pelvic cancer. Improved radiotherapy techniques with smaller irradiated bladder and bowel volumes have probably resulted in less toxicities. Future studies on genetic markers of toxicity should be powered on these lower incidences. We further recommend taking persistency, next to severity, into consideration.
Authors
- Nicolaas A.P. Franken (ORCID: https://orcid.org/0000-0002-5522-9406)
- Lukas J.A. Stalpers (ORCID: https://orcid.org/0000-0001-9574-0295)
- Ron A. Hoebe (ORCID: https://orcid.org/0000-0002-1553-4342)
- C. Rasch (ORCID: https://orcid.org/0000-0001-6950-3376)
- Anna C. Nuijens (ORCID: https://orcid.org/0000-0001-9154-7658)
- Arlene L. Oei (ORCID: https://orcid.org/0000-0002-6936-1934)
- L.E. Koster
Institutions
- Dutch Cancer Society (NL)
- Leiden University Medical Center (NL)
- Amsterdam UMC Location University of Amsterdam (NL)
- Amsterdam University Medical Centers (NL)
- Cancer Center Amsterdam (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Radiation Oncology
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1186/s13014-024-02501-x
- Citations
- 5
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Amsterdam University Medical Centers
- KWF Kankerbestrijding