The Best Start Trial: A randomised controlled trial of ultra-early parent-administered physiotherapy for infants at high risk of cerebral palsy or motor delay
In this pilot trial, there was no clinically worthwhile effect of ultra-early parent-administered physiotherapy over usual care on the AIMS. However, the intervention was feasible for infants, acceptable to parents and parents perceived a benefit of treatment. Whilst this trial did not demonstrate treatment effectiveness using the AIMS, these findings should be interpreted cautiously because of the small sample size, the low responsivity of the AIMS to change in motor performance and the heterogeneity of the participants. Therefore, the intervention should not be abandoned on the basis of this trial, but rather further evaluated in a larger trial that addresses some of the learnings from this one.
Authors
- Genevieve Dwyer (ORCID: https://orcid.org/0000-0003-4176-1546)
- Lisa A. Harvey (ORCID: https://orcid.org/0000-0002-4365-0236)
- Iona Novak (ORCID: https://orcid.org/0000-0001-6001-4867)
- Elizabeth Jane Elliott (ORCID: https://orcid.org/0000-0002-6501-5487)
- Barbara R. Lucas (ORCID: https://orcid.org/0000-0003-0558-8993)
- Nadia A. Badawi (ORCID: https://orcid.org/0000-0001-6828-1636)
- V. Venkatesha (ORCID: https://orcid.org/0000-0002-2799-2535)
- Catherine Morgan (ORCID: https://orcid.org/0000-0003-3670-0845)
- J. Richard Bowen
Institutions
- The University of Sydney (AU)
- New South Wales Department of Health (AU)
- Cerebral Palsy Alliance (AU)
- Royal North Shore Hospital (AU)
- Northern Sydney Local Health District (AU)
- Sydney Local Health District (AU)
- Sydney Children’s Hospitals Network (AU)
- Western Sydney University (AU)
Publication Details
- Journal
- Early Human Development
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1016/j.earlhumdev.2024.106111
- Citations
- 4
- Primary Topic
- Infant Development and Preterm Care
- Type
- article
- Field-Weighted Citation Impact
- 4.44