Age-Related Differences in Rejection Rates, Infections, and Tacrolimus Exposure in Pediatric Kidney Transplant Recipients in the CERTAIN Registry
This is the largest study to date in European pKTRs on a tacrolimus-based immunosuppressive regimen, and it shows important age-related differences in rejection rates, infection episodes, as well as tacrolimus exposure and clearance. This data suggests that immunosuppressive therapy in pKTRs should be tailored and personalized according to the age-specific risk profiles of this heterogeneous patient population. The data may serve as a benchmark for future studies with novel immunosuppressive drugs.
Authors
- Alexander Fichtner (ORCID: https://orcid.org/0000-0002-9939-4059)
- Licia Peruzzi (ORCID: https://orcid.org/0000-0002-5704-3867)
- Birgitta Kranz
- Jun Oh (ORCID: https://orcid.org/0000-0003-1846-675X)
- Atif Awan (ORCID: https://orcid.org/0000-0002-1615-2602)
- Lutz T. Weber (ORCID: https://orcid.org/0000-0003-4116-598X)
- Anja Büscher (ORCID: https://orcid.org/0000-0001-5582-0557)
- Kai Krupka (ORCID: https://orcid.org/0000-0002-0409-5196)
- Isabella Guzzo (ORCID: https://orcid.org/0000-0003-4960-3083)
- Jon Jin Kim (ORCID: https://orcid.org/0000-0003-4307-8513)
- Britta Höcker (ORCID: https://orcid.org/0000-0003-4131-2273)
- Elisa Benetti (ORCID: https://orcid.org/0000-0002-4481-0756)
- Lars Pape (ORCID: https://orcid.org/0000-0002-3635-6418)
- Mieczysław Litwin (ORCID: https://orcid.org/0000-0002-5241-2483)
- Mohan Shenoy (ORCID: https://orcid.org/0000-0002-2456-3006)
- Manuel Feißt (ORCID: https://orcid.org/0000-0002-5016-9731)
- Ali Düzova (ORCID: https://orcid.org/0000-0002-4365-2995)
- Sara Testa (ORCID: https://orcid.org/0000-0003-3062-8985)
- Maral Baghai Arassi (ORCID: https://orcid.org/0000-0002-8957-7767)
- Jakub Zieg
- Burkhard Tönshoff
Institutions
- Nottingham University Hospitals NHS Trust (GB)
- University of Padua (IT)
- Universität Hamburg (DE)
- University of Cologne (DE)
- Charles University (CZ)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Temple Street Children's University Hospital (IE)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- University Hospital in Motol (CZ)
- Zimmer Biomet (Germany) (DE)
- University Hospital Münster (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Children's Memorial Health Institute (PL)
- Essen University Hospital (DE)
- Bambino Gesù Children's Hospital (IT)
- European Molecular Biology Laboratory (DE)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- European Molecular Biology Laboratory (DE)
- University Hospital Cologne (DE)
- Royal Manchester Children's Hospital (GB)
- Hacettepe University (TR)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1016/j.ekir.2024.08.025
- Citations
- 11
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.59
Funders
- Astellas Pharma