Proteomic profile of extracellular vesicles from plasma and CSF of multiple sclerosis patients reveals disease activity-associated EAAT2
Our results emphaticize the usefulness of plasma EVs as a source of accessible biomarkers to remotely analyse the CNS status. Plasma EV-EAAT2 showed to be a promising biomarker for MS relapses. Further studies are required to assess the clinical relevance of this biomarker also for disability progression independent of relapse activity and transition from RRMS towards SPMS.
Authors
- Simona Pontecorvo (ORCID: https://orcid.org/0000-0002-4256-2568)
- Vittorio Di Piero (ORCID: https://orcid.org/0000-0002-2631-7562)
- Paola Margutti (ORCID: https://orcid.org/0000-0003-1814-9084)
- Marialuisa Casella (ORCID: https://orcid.org/0000-0003-0245-6709)
- Serena Camerini (ORCID: https://orcid.org/0000-0001-6131-4335)
- Marta Altieri (ORCID: https://orcid.org/0000-0003-3110-5932)
- Marco Puthenparampil (ORCID: https://orcid.org/0000-0002-2313-8462)
- Ada Francia (ORCID: https://orcid.org/0000-0002-9550-9082)
- Nicola Vanacore (ORCID: https://orcid.org/0000-0003-2817-3758)
- S Zamboni (ORCID: https://orcid.org/0000-0002-0859-7329)
- Donatella Pietraforte (ORCID: https://orcid.org/0000-0001-6370-912X)
- Paolo Gallo (ORCID: https://orcid.org/0000-0003-3886-4181)
- Marco Diociauti
- Massimo Sanchez (ORCID: https://orcid.org/0000-0003-3696-7582)
- Antonella D’Ambrosio
Institutions
- University of Padua (IT)
- Istituto Superiore di Sanità (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1186/s12974-024-03148-x
- Citations
- 12
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Ministero della Salute