Quantification of alcohol intake in patients with steatotic liver disease and excessive alcohol intake
An accurate quantification of alcohol intake is crucial in the clinical phenotyping of patients with steatotic liver disease and when designing clinical trials. This study found self-reported abstinence to be reliable but phosphatidylethanol was a more accurate prognostic biomarker of hepatic decompensation and death in a clinical trial setting. Findings may inform the design of future trials in patients with steatotic liver disease.
Authors
- Camilla Dalby Hansen (ORCID: https://orcid.org/0000-0002-5704-2485)
- Gitte Hedegaard Jensen
- Katrine Holtz Thorhauge (ORCID: https://orcid.org/0000-0003-0411-0373)
- Peter Andersen (ORCID: https://orcid.org/0009-0001-4278-3731)
- K. Bech (ORCID: https://orcid.org/0000-0002-3760-0689)
- Emmanuel Tsochatzis (ORCID: https://orcid.org/0000-0001-5069-2461)
- Katrine Prier Lindvig (ORCID: https://orcid.org/0000-0001-7891-7706)
- Jonel Trebicka (ORCID: https://orcid.org/0000-0002-7028-3881)
- Mads Israelsen (ORCID: https://orcid.org/0000-0001-9443-5846)
- Ida Falk Villesen (ORCID: https://orcid.org/0000-0001-7921-9707)
- Stine Johansen (ORCID: https://orcid.org/0000-0002-5031-2294)
- Aleksander Krag (ORCID: https://orcid.org/0000-0002-9598-4932)
- Johanne Kragh Hansen (ORCID: https://orcid.org/0000-0003-2898-5369)
- Nikolaj Torp (ORCID: https://orcid.org/0000-0002-4378-6256)
- Maja Thiele (ORCID: https://orcid.org/0000-0003-1854-1924)
- M Bergmann (ORCID: https://orcid.org/0000-0001-9213-3676)
- Sönke Detlefsen (ORCID: https://orcid.org/0000-0002-9466-2333)
- Torben Hansen (ORCID: https://orcid.org/0000-0001-8748-3831)
- Emil Deleuran Hansen
Institutions
- University of Copenhagen (DK)
- University of Southern Denmark (DK)
- Novo Nordisk Foundation (DK)
- The Royal Free Hospital (GB)
- Odense University Hospital (DK)
- European Foundation for the Study of Chronic Liver Failure (ES)
- University Hospital Münster (DE)
- Region of Southern Denmark (DK)
- University College London (GB)
Publication Details
- Journal
- JHEP Reports
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1016/j.jhepr.2024.101200
- Citations
- 21
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 8.12
Funders
- Novo Nordisk Fonden
- HORIZON EUROPE Framework Programme