Association between interleukin-12 p40 subunit and risk of primary Sjögren’s disease: a Mendelian randomization study
This study provides genetic evidence that IL-12p40 has a causal role in primary Sjögren's disease pathogenesis. Our data suggest that decreasing levels of IL-12p40 may be deleterious. We would not suggest selecting this drug target as a therapeutic option.
Authors
- James Benjamin Galloway (ORCID: https://orcid.org/0000-0002-1230-2781)
- Mark Russell (ORCID: https://orcid.org/0000-0001-8171-7772)
- Sizheng Steven Zhao (ORCID: https://orcid.org/0000-0002-3558-7353)
- Benjamin Zuckerman (ORCID: https://orcid.org/0000-0002-0077-6074)
- Alasdair Warwick (ORCID: https://orcid.org/0000-0002-0800-2890)
- Chris Wincup (ORCID: https://orcid.org/0000-0002-8742-8311)
- Zijing Yang (ORCID: https://orcid.org/0000-0001-7173-0631)
Institutions
- Moorfields Eye Hospital NHS Foundation Trust (GB)
- King's College London (GB)
- Manchester Academic Health Science Centre (GB)
- University of Manchester (GB)
- Moorfields Eye Hospital (GB)
- University College London (GB)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1093/rheumatology/keae475
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AstraZeneca