Retinal changes in preeclampsia

Background: The eye undergoes a series of physiological changes during pregnancy in response to metabolic and hormonal adaptation. Preeclampsia (PE) is the main cause of maternal morbidity and is associated with serious pregnancy-related complications. Characterized by hypertension and proteinuria, PE affects 2–8% of pregnancies globally. Previous studies have indicated that PE compromises retinal health. We examined the effects of PE on retinal structure and vasculature. Methods: We conducted a literature review by searching PubMed/MEDLINE, Embase, and Scopus using terms pertaining to PE and the retina. The review included articles published between January 1, 1990, and May 30, 2024. The articles were selected based on their relevance to the topic. The key findings are summarized to offer a comprehensive overview of current knowledge, highlight the pathophysiology and manifestations of PE-related retinal changes, and propose clinical implications, diagnostic clues, and management strategies. Results: PE is associated with visual disturbances caused by various retinal changes, including arteriolar narrowing, vasospasm, hemorrhages, exudates, serous retinal detachment, macular edema, retinal vein occlusion, and choroidal ischemia. These are mostly evident on fundus examination and frequently resolve postpartum. The underlying pathophysiology involves endothelial dysfunction, hypertension, inflammation, and coagulopathy. These retinal changes have immediate clinical implications and long-term risks, necessitating early detection, prompt multidisciplinary management, and close follow-up. Although most PE-associated retinal disturbances spontaneously resolve after the termination of pregnancy, one-third of patients are likely to experience long-lasting consequences Conclusions: Visual disturbances may precede and portend the onset of PE. Early detection and prompt management will mitigate fetal and maternal morbidity and mortality. Understanding the underlying pathophysiology of PE-related retinal manifestations is crucial for optimal management, because the majority of manifestations are reversible. Although retinal changes secondary to PE typically resolves postpartum, some studies demonstrated that women with PE may have a higher long-standing risk of ocular disorders. A multidisciplinary team approach involving obstetricians, ophthalmologists, and healthcare providers is essential for the immediate and long-term management of ocular consequences in pregnancy. Consequently, additional studies associated with robust methodologies are required to develop clinical guidelines.