Ginsenoside Rh2 suppresses ferroptosis in ulcerative colitis by targeting specific protein 1 by upregulating microRNA-125a-5p
Rh2 mitigated DSS-induced colitis in mice and restrained ferroptosis by targeting miR-125a-5p. Downregulating miR-125a-5p or elevating SP1 could counteract the protective impacts of Rh2 on ferroptotic cells. The findings convey that Rh2 has a latent application value in the treatment of UC.
Authors
- Dejun Cui (ORCID: https://orcid.org/0000-0002-3653-3058)
- WenQiang Yuan
- Liu-chan Yang
- Xun Zhao (ORCID: https://orcid.org/0000-0001-5391-5800)
- Fang Yan (ORCID: https://orcid.org/0000-0003-4959-2433)
Institutions
- Guizhou University (CN)
- Guizhou Provincial People's Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1186/s40001-024-02025-w
- Citations
- 6
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.71