HADH suppresses clear cell renal cell carcinoma progression through reduced NRF2-dependent glutathione synthesis
Our data revealed that HADH suppressed the malignant behaviors of ccRCC cells by attenuating GSH synthesis through inhibition of NRF2 nuclear translocation, and HADH might be a novel therapeutic target for ccRCC treatment.
Authors
- Changbin Chu
- Xueya Zhao
- Shangjing Liu (ORCID: https://orcid.org/0000-0003-0811-7900)
- Rui Cheng (ORCID: https://orcid.org/0000-0002-3003-8339)
- Zhiting He
- Hongxiang Zeng (ORCID: https://orcid.org/0000-0002-3028-9007)
- Jing Xia
- Xi Li (ORCID: https://orcid.org/0000-0002-2716-7308)
- Mingjun Wu
- Wenhua Xie
Institutions
- Army Medical University (CN)
- Xinqiao Hospital (CN)
- Chongqing Emergency Medical Center (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1016/j.tranon.2024.102112
- Citations
- 4
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.14
Funders
- National Natural Science Foundation of China
- Chongqing Medical University
- Natural Science Foundation of Chongqing
- Chongqing Municipal Education Commission
- National Key Research and Development Program of China