Phosphodiesterase 4 is overexpressed in keloid epidermal scars and its inhibition reduces keratinocyte fibrotic alterations
Overall, the study supports the potential of PDE4 inhibitors, particularly PDE4B, in treating skin fibrosis, including keloids and HTS, shedding light on their functional role in this condition.
Authors
- Pilar Ribera (ORCID: https://orcid.org/0000-0002-2883-5611)
- Paula Montero (ORCID: https://orcid.org/0000-0002-5929-5486)
- Javier Milara (ORCID: https://orcid.org/0000-0001-6033-4211)
- Inés Roger (ORCID: https://orcid.org/0000-0001-7741-6600)
- Julio Cortijo (ORCID: https://orcid.org/0000-0003-1724-4784)
- Severiano Marín
Institutions
- Universitat de València (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- Hospital General Universitario De Valencia (ES)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1186/s10020-024-00906-8
- Citations
- 7
- Primary Topic
- Dermatologic Treatments and Research
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- Ministerio de Ciencia e Innovación
- Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares
- Instituto de Salud Carlos III
- Conselleria de Sanitat Universal i Salut Pública
- Eurostars