The Risk for Excessive Anticoagulation With Activated Clotting Time-Guided Monitoring in Patients Undergoing Transcatheter Aortic Valve Replacement

•An activated clotting time <250 ​seconds after an initial unfractionated heparin dose often coincided with sufficient antifactor Xa activity >0.50 U/mL, which may result in additional unfractionated heparin administration, with an increased bleeding risk.•The point-of-care-activated partial thromboplastin time may be a safer and more reliable anticoagulation monitoring tool during transcatheter aortic valve replacement procedures.