Genome binding properties of Zic transcription factors underlie their changing functions during neuronal maturation
Our data show that Zic TFs are required for both induction and repression of distinct, developmentally regulated target genes through a mechanism that is largely independent of changes in Zic TF binding. We suggest that the differential collaboration of Zic TFs with other TF families underlies the shift in their biological functions across CGN development.
Authors
- Anne E. West (ORCID: https://orcid.org/0000-0003-0846-139X)
- Melyssa S. Minto (ORCID: https://orcid.org/0000-0002-5438-7285)
- Jesús Emiliano Sotelo-Fonseca (ORCID: https://orcid.org/0000-0003-1600-2396)
- Vijyendra Ramesh (ORCID: https://orcid.org/0000-0001-8818-6863)
Institutions
- Duke University (US)
- RTI International (US)
Publication Details
- Journal
- BMC Biology
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1186/s12915-024-01989-9
- Citations
- 5
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Northwestern University
- Carnegie Mellon University
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke