Identification of a novel DNA oxidative damage repair pathway, requiring the ubiquitination of the histone variant macroH2A1.1
Our data identify a novel pathway for the repair of DNA oxidative lesions, requiring the ubiquitination of mH2A for the release of PARP-1 from chromatin and its activation.
Authors
- Christian Bronner (ORCID: https://orcid.org/0000-0002-3101-9279)
- Ahmed Bahieldin (ORCID: https://orcid.org/0000-0002-6496-7881)
- Flore Mietton
- Ali T. Zari
- Annie Molla (ORCID: https://orcid.org/0000-0002-9859-8682)
- Stéfan Dimitrov (ORCID: https://orcid.org/0000-0002-1326-3630)
- Jamal S. M. Sabir (ORCID: https://orcid.org/0000-0003-4785-9894)
- Ali Hamiche (ORCID: https://orcid.org/0000-0002-7859-6372)
- Hervé Menoni (ORCID: https://orcid.org/0000-0002-5302-4933)
- Abdulkhaleg Ibrahim (ORCID: https://orcid.org/0000-0002-1035-8044)
- Raed S. Albheyri
- Khalid Ouararhni
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- King Abdulaziz University (SA)
- Institut de génétique et de biologie moléculaire et cellulaire (FR)
- Institute of Molecular Biology (BG)
- National Clinical Research (US)
- Université de Strasbourg (FR)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- BMC Biology
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1186/s12915-024-01987-x
- Citations
- 2
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Fondation pour la Recherche Médicale
- Université de Strasbourg
- King Abdulaziz University
- Centre National de la Recherche Scientifique
- Laboratoire d'Excellence INRT