Prostatic lineage differentiation from human embryonic stem cells through inducible expression of NKX3-1
This study reveals the crucial role of NKX3-1 in prostatic differentiation and offers the inducible NKX3-1 cell line, as well as provides a stepwise differentiation protocol to generate human prostate-like organoids, which should facilitate the studies on prostate development and disease pathogenesis.
Authors
- Xinghuan Wang (ORCID: https://orcid.org/0000-0003-3497-0024)
- Yinglei Li (ORCID: https://orcid.org/0000-0002-0624-7165)
- Tianzhe Zhang (ORCID: https://orcid.org/0000-0002-7114-3573)
- Yangyang Yu (ORCID: https://orcid.org/0000-0002-2754-5954)
- Ran Liu (ORCID: https://orcid.org/0000-0001-8150-6799)
- Wei Jiang (ORCID: https://orcid.org/0000-0002-6463-7356)
- Songwei Wang
Institutions
- Jianghan University (CN)
- Wuhan University (CN)
- Hubei Provincial Center for Disease Control and Prevention (CN)
- Zhongnan Hospital of Wuhan University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1186/s13287-024-03886-y
- Primary Topic
- Tissue Engineering and Regenerative Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China