Impact of sympathetic hyperactivity induced by brain microglial activation on organ damage in sepsis with chronic kidney disease
In septic rats with concomitant CKD, SNA was significantly enhanced and organ dysfunction was increased. It has been suggested that the mechanism of exacerbated organ dysfunction in these models may involve abnormal systemic hemodynamics, possibly triggered by activation of the central sympathetic nervous system through activation of microglia in the PVN.
Authors
- Shota Ikeda (ORCID: https://orcid.org/0000-0003-1358-524X)
- Masaaki Nishihara (ORCID: https://orcid.org/0000-0001-8903-7923)
- Tomohiko Akahoshi (ORCID: https://orcid.org/0000-0002-1750-2299)
- Hiroyuki Tsutsui (ORCID: https://orcid.org/0000-0002-5291-2875)
- Keisuke Shinohara (ORCID: https://orcid.org/0000-0002-3084-1711)
Institutions
- Kyushu University (JP)
- Fukuoka International University (JP)
- Kyushu University Hospital (JP)
Publication Details
- Journal
- Journal of Intensive Care
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1186/s40560-024-00742-2
- Primary Topic
- Heart Rate Variability and Autonomic Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science